Psychedelic drugs take on depression (2024)

  • OUTLOOK

Mind-altering drugs might provide relief for those who don’t respond to conventional therapies — but does the hype outweigh the hope?

    By
  • Cassandra Willyard0
  1. Cassandra Willyard
    1. Cassandra Willyard is a science journalist in Madison, Wisconsin.

    View author publications

    You can also search for this author in PubMed Google Scholar

  • Twitter
  • Facebook
  • Email

Tom Hendricks lay back on his bed and pulled a mask down over his eyes. Then he took a ketamine mint and placed it between his cheek and gums. He let the electronic music coming through his headphones wash over him. About 20 minutes later, he felt the drug take effect. He saw colours and shapes that changed in time with the music. “It almost was a synaesthesia effect where the sounds and music would paint pictures,” he says. Embedded within those pictures, Hendricks saw his consciousness and the dark cloud hanging over it.

Access options

Access through your institution

Change institution

Buy or subscribe

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

£14.99 /30days

cancel any time

Learn more

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 608, S36-S38 (2022)

doi: https://doi.org/10.1038/d41586-022-02205-w

This article is part of Nature Outlook: Depression, an editorially independent supplement produced with the financial support of third parties. About this content.

References

  1. Berman, R. M. et al. Biol. Psychiatry 47, 351–354 (2000).

    Article PubMed Google Scholar

  2. McInnes, L. A., Qian, J. J., Gargeya, R. S., DeBattista, C. & Heifets, B. D. J. Affect. Disord. 301, 486–495 (2022).

    Article PubMed Google Scholar

  3. Popova, V. et al. Am. J. Psychiatry 176, 428–438 (2019).

    Article PubMed Google Scholar

  4. Daly, E. J. et al. JAMA Psychiatry 76, 893–903 (2019).

    Article PubMed Google Scholar

  5. Highland, J. N. et al. ACS Chem. Neurosci. 13, 510–523 (2022).

    Article PubMed Google Scholar

  6. Feys, F., Bekkering, G. E., Singh, K. & Devroey, D. Syst. Rev. 1, 54 (2012).

    Article PubMed Google Scholar

  7. Carhart-Harris, R. et al. N. Engl. J. Med. 384, 1402–1411 (2021).

    Article PubMed Google Scholar

  8. Daws, R. E. et al. Nature Med. 28, 844–851 (2022).

    Article PubMed Google Scholar

Download references

Related Articles

  • A journey into the causes and effects of depression

  • Tackling the mental-health crisis in young people

  • The vicious cycle of depression and obesity

  • The hormonal keys to depression

  • Wiring up the brain to beat depression

  • Brain-cell growth keeps mood disorders at bay

  • Can resetting the body clock help with depression?

  • Research round-up: depression

  • Why depression in women is so misunderstood

Subjects

  • Depression
  • Psychiatric disorders
  • Drug discovery
  • Psychology

Latest on:

Substrate binding and inhibition mechanism of norepinephrine transporter Article 14 AUG 24
MDMA therapy for PTSD rejected by FDA panel News 05 JUN 24
Internet use and teen mental health: it’s about more than just screen time Correspondence 21 MAY 24
Detecting hidden brain injuries Outlook 29 AUG 24
FDA rejects ecstasy as a therapy: what’s next for psychedelics? News 13 AUG 24
Fibrin drives thromboinflammation and neuropathology in COVID-19 Article 28 AUG 24
Debate rages over Alzheimer’s drug lecanemab as UK limits approval News 22 AUG 24
Human organoids with an autologous tissue-resident immune compartment Article 14 AUG 24

Psychedelic drugs take on depression (18)

Jobs

  • Division Director - Experimental Hematology and Cancer Biology

    Cincinnati Children’s Hospital seeks the next Director for the Division of Experimental Hematology and Cancer Biology.

    Cincinnati, Ohio

    Cincinnati Children's Hospital & Medical Center

    Psychedelic drugs take on depression (19)

  • Faculty and Research Positions, Postdoctoral Recruitment

    Jointly sponsored by the Hangzhou Municipal People's Government and the University of Chinese Academy of Sciences.

    Hangzhou, Zhejiang, China

    Hangzhou Institute of Advanced Study, UCAS

    Psychedelic drugs take on depression (20)

  • Associate or Senior Editor, Nature Energy

    Job Title:Associate or Senior Editor,Nature Energy Location:New York, Jersey City, Philadelphia or London — Hybrid Working Application Deadline:...

    New York City, New York (US)

    Springer Nature Ltd

    Psychedelic drugs take on depression (21)

  • IOP is the leading research institute in China in condensed matter physics and related fields. Through the steadfast efforts of generations of scie...

    Beijing, China

    Institute of Physics (IOP), Chinese Academy of Sciences (CAS)

    Psychedelic drugs take on depression (22)

  • FACULTY POSITION IN THE MOLECULAR BIOLOGY OF REPRODUCTION

    FACULTY POSITION IN THE MOLECULAR BIOLOGY OF REPRODUCTION

    Dallas, Texas (US)

    The University of Texas Southwestern Medical Center (UT Southwestern Medical Center)

    Psychedelic drugs take on depression (23)

Access through your institution

Change institution

Buy or subscribe

Related Articles

  • A journey into the causes and effects of depression

  • Tackling the mental-health crisis in young people

  • The vicious cycle of depression and obesity

  • The hormonal keys to depression

  • Wiring up the brain to beat depression

  • Brain-cell growth keeps mood disorders at bay

  • Can resetting the body clock help with depression?

  • Research round-up: depression

  • Why depression in women is so misunderstood

Subjects

  • Depression
  • Psychiatric disorders
  • Drug discovery
  • Psychology

Sign up to Nature Briefing

An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday.

Psychedelic drugs take on depression (2024)
Top Articles
Latest Posts
Article information

Author: Wyatt Volkman LLD

Last Updated:

Views: 6368

Rating: 4.6 / 5 (66 voted)

Reviews: 81% of readers found this page helpful

Author information

Name: Wyatt Volkman LLD

Birthday: 1992-02-16

Address: Suite 851 78549 Lubowitz Well, Wardside, TX 98080-8615

Phone: +67618977178100

Job: Manufacturing Director

Hobby: Running, Mountaineering, Inline skating, Writing, Baton twirling, Computer programming, Stone skipping

Introduction: My name is Wyatt Volkman LLD, I am a handsome, rich, comfortable, lively, zealous, graceful, gifted person who loves writing and wants to share my knowledge and understanding with you.